Melissa McCarthy as Detective Connie Edwards

Bill Barretta as Phil Philips / Junkyard / Boar

Leslie David Baker as Lt. Banning

Elizabeth Banks as Jenny

Joel McHale as Agent Campbell

Maya Rudolph as Bubbles

Dorien Davies as Sandra

Drew Massey as Goofer / Vinny

Kevin Clash as Bumblypants / Lyle

Michael McDonald as Ronovan Scargle

Cynthy Wu as Brittenie Marlowe

Mitch Silpa as Tommy

Hemky Madera as Tito

Benjamin Royer as Rick

Brekkan Spens as Dick

Ryan Tran as Phil

Fortune Feimster as Robin

Brian Palermo as Paramedic

Damon Jones as Police Station Guard John / Puppet Doctor

Ryan Gaul as Officer Milligan

Jimmy O. Yang as Officer Delancey

Dennis Keiffer as Junior

Jim Palmer as Caesar

Michael Croner as Jack Cook

Barry Rothbart as Fireman

Steve Mallory as Kerry

Dana Schick as Pretty Girl

Jaye Razor as Razor

Jen Sung as Sandra's Bodyguard

Bryan Cartago as Sandra's Bodyguard

Brett Wagner as Rio

Colleen Smith as Carol / Dalmatian / Cara

Ben Falcone as Donny

Victor Yerrid as Larry / Old Man Puppet

Ted Michaels as Sexist Thug / Ezra

Brian Henson as Crab

Patty Guggenheim as Roxy

Donna Kimball as Roxy / Cow / Rotten Cotton Girl

Alice Dinnean as Rotten Cotton Girl

Allan Trautman as Octopus / Puppet Doctor