Kate Hudson as Skye Davidson

Brendan Sexton III as Blue Baxter

John Heard as Prof. Lance Davidson

Christina Ricci as Ely Jackson

Casey Affleck as Pete Kepler

Sara Gilbert as Sandy

Ethan Suplee as Cale

Peter Sarsgaard as Billy Baxter

Lucinda Jenney as Caroline Baxter

Michael Ironside as Agent Frank Bellows

Daniel von Bargen as Sheriff Jackson

Aunjanue Ellis-Taylor as Agent Summers

Lee Holmes as Deputy Keeler

Isidra Vega as Haley Gordon

Rene Rivera as Dr. Gordon

Fred Schneider as KBLU Radio DJ (voice)

Liev Schreiber as Mickey Moonday (voice)

Richmond Arquette as Truck Driver

Jerry Agee as Insurance Agent

Ntare Guma Mbaho Mwine as Agent Green