Elio Germano as Francesco

Jérémie Renier as Elia da Cortona

Alba Rohrwacher as Chiara

Stefano Cassetti as Bonizzio

Thomas Doret as Étienne

Yannick Renier as Dominique

Éric Caravaca as Leone

Marcello Mazzarella as Fra Rufino

Olivier Gourmet as Cardinal Hugolin

Catherine Chevallier as Clarisse

Philippe Laudenbach as Papa Innocenzo III