Charlie Adler as Grammy (voice)

Jeff Bennett as Steed (voice)

John DiMaggio as J.W. / Spike (voice)

Jess Harnell as Buzz Blister / Film Director (voice)

Tom Kenny as Gorthan / Whale (voice)

Bill Kopp as Tom / Frank (voice)

Tress MacNeille as Soccer Mom / Lady / Tour Girl (voice)

Rob Paulsen as Irving / Dave (voice)

Billy West as Biff Buzzard / President of Hollywood / Squirty (voice)

J. Grant Albrecht as Clown-O / Security Guard (voice)

Thom Pinto as Computer / Guard (voice)

Neil Ross as Dr. Professor / Director (voice)

Renna Nightingale as Lauren