Javier Bardem as Pablo Escobar

Penélope Cruz as Virginia Vallejo

Peter Sarsgaard as Shepard

Julieth Restrepo as Maria Victoria Henao

Óscar Jaenada as Santoro

David Valencia as Santos

Mark Basnight as Family Man

Joavany Alvarez as Ignacio Velarde

Matthew Moreno as Pablito

David Ojalvo as FBI Agent

Fredy Yate as Pelado

Ricardo Niño as Careta

Pedro Calvo as Gatillero

Santiago Londoño as Hermosilla

Juan Sebastián Calero as Carlos Corral

Quique Mendoza as Abel Monje

Ariel Sierra as Salvador Martín

Julio Nava as Garza

Miguel Such as Victor

Atanas Srebrev as Agent Holland

Carlos Ramírez as Juan Pablo (8 years)

Tania Valencia as Chantal

Erik Rodriguez as Boy from the Slums

Sara Deray as Paula

Patrick Forster-Delmas as Producer

Lillian Blankenship as Family Man's Daughter

Georgi Nikolov as Hitman #1

Mihail Stoyanov as Hitman #2

Nathan Cooper as Cop #1

Andrew De La Rocha as Cop #2

Colin Salmon as High State US Official

Santiago Soto as Ignacio Castro

Bernardo García as Cali Delegate

Oscar Rodriguez as Campaign Manager

Simón Rivera as Rodrigo Lara Bonilla

Carlos-Manuel Vesga as La Plaga

Álvaro García as Alfonso López Michelsen

Catalina Londoño as Nurse

Pedro Ochoa as Doctor Panama Clinic

Douglas Ceballos as Judge Alarcón

Francisco Bolívar as Gunman

Luis Fernando Hoyos as Colonel Méndez

Juan Pablo Gamboa as Director TV

Karine Amaya as Attractive Blonde Presenter

Andrea Vidal as Teenager

Heisel Mora as Airline Employee

Emilia Klayn as Secretary

Alejandro Ruiz as Soccer Announcer

Herbert King as Pawn Shop Attendant

Ricardo Vélez as Surgeon

Nicolas Gonzales as Juan Pablo (Teenager)

Hannah L'Hoeste as Manuela (4 Years)

Manuel José Chaves as Samuel Elizondo

Giselle Da Silva as Olguita Arranz

Juan David Agudelo as Puppy Dog

Nina Caicedo as Woman

Jorge Monterrosa as Young Man

Juan Carlos Ortega as Locutor

Santiago Lozano as Hitman

Alberto Pablo Rivera as Family Man

Juan Castillo as Employee

Cristian Rojas as Judge Alarcón's Son (8 Years)

Juan Sábato as Operator 1

Andrés Felipe Calero as News Anchor

Norma Nivia as Reporter

Diego Landaeta as Phone Technician

David Trejos as Passenger

Jorge Alberto Reyes as Janitor

Juan Angulo as Subordinate

Alexander Acosta-Osorio as Workers' Leader

Juan Vela as Worker

Mihail Rangelov as Monje Double

Plamen-Kaloyan Todorv as Hitman #3

Philip Lind-Bendixen as US Marine Soldier

Juan Camilo Castillo as Funeral Employee

Diana Wiswell as Nurse

Quique Mendosa as Abel Monje

Julio Navas as Garza

James Lawrence as Embajador William

Juan Carlos Ortega as locutor

Carlos Carvajal as Stage Manager