Tom Hardy as Al Capone

Linda Cardellini as Mae Capone

Matt Dillon as Johnny

Kyle MacLachlan as Doctor Karlock

Kathrine Narducci as Rosie

Jack Lowden as Crawford

Noel Fisher as Junior

Tilda Del Toro as Mona Lisa

Al Sapienza as Ralphie

Mason Guccione as Tony

Jhemma Ziegler as Betty

Rose Bianco as Nanna

Wayne Pére as Director Nordhoff

Gino Cafarelli as Gino

Manuel Fajardo as Zambini

Christopher Bianculli as Young Tony

Edgar Arreola as Rodrigo

CG Lewis as Young Goon

David Wachs as Dying Goon

Josh Trank as Agent Harris

Neal Brennan as Harold Mattingly

Jason Edwards as Drunk Dancing Man

Caiden Acurio as Vince

Mason Rozas as Danny

Emma Kathryn Coleman as Gabi

Tara Foy as Roberta

Reed Luckett Wiley as Mysterious Man #1

Troy Warren Anderson as Louis Armstrong

Andreanna L. Jenson as Nurse Lianne

Cameron Stout as FBI Agent (uncredited)

Jesse Mattson as Gino's Goon