Robert Alda as George Gershwin

Joan Leslie as Julie Adams

Alexis Smith as Christine Gilbert

Charles Coburn as Max Dreyfus

Julie Bishop as Lee Gershwin

Albert Bassermann as Prof. Franck

Morris Carnovsky as Morris Gershwin

Rosemary DeCamp as Rose Gershwin

Oscar Levant as Oscar Levant

Paul Whiteman as Paul Whiteman

Al Jolson as Al Jolson

George White as George White

Hazel Scott as Hazel Scott

Anne Brown as Bess

Herbert Rudley as Ira Gershwin

John B. Hughes as Hughes

Mickey Roth as George Gershwin as a Boy

Darryl Hickman as Ira Gershwin as a Boy

Charles Halton as Mr. Kast

Andrew Tombes as Mr. Million

Gregory Golubeff as Mr. Katzman

Walter Soderling as Mr. Muscatel

Eddie Marr as Buddy De Sylva

Theodore von Eltz as Foley

Bill Kennedy as Herbert Stone

Oscar Loraine as Maurice Ravel

Johnny Downs as Dancer

Ernest Golm as Otto Kahn

Martin Noble as Jascha Heifetz

Hugo Kirchhoffer as Walter Damrosch

Will Wright as Rachmaninoff

Lynn Baggett as Guest (uncredited)

Gower Champion as Tap Dancer at Remick's (uncredited)

Elsa Maxwell as Elsa Maxwell (uncredited)

Mark Stevens as Steve (uncredited)

Charles Waldron as Doctor (uncredited)

Bernard DeRoux as Porter (uncredited)

Joe Gilbert as Nightclub Patron (uncredited)