Jennifer Lopez as Charlie

Jane Fonda as Viola Fields

Michael Vartan as Dr. Kevin Fields

Wanda Sykes as Ruby

Adam Scott as Remy

Monet Mazur as Fiona

Annie Parisse as Morgan

Will Arnett as Kit

Elaine Stritch as Gertrude

Stephen Dunham as Dr. Paul Chamberlain

Randee Heller as Beverly Hills Dog Owner

Mark Moses as Coffee Shop Customer

Tomiko Fraser as Coffee Shop Clerk

Rochelle Flexer as Dr. Patel's Nurse

Wayne Nickel as George

Jenny Wade as Viola's Young Replacement

Bruce Gray as TV Executive

Zach McLarty as Assistant Director

Stephanie Turner as Tanya Murphy the Pop Star

Harriet Sansom Harris as Therapist

Jimmy Jean-Louis as Prince Amir

Christopher Scott as Prime Minister

Pamela Rowan as Woman Club Member

Monica Guiza as Rehearsal Dinner Guest

Amber Mead as Kit's Date

Christina Masterson as Pretty Young Thing at Wedding

Kristen Aldridge as Boutique Salesgirl (uncredited)

Olivia Alexander as Ashley (uncredited)

John Aylward as Priest (uncredited)

Amie Barsky as Waitress (uncredited)

Jed Bernard as Party Guest (uncredited)

Lorenzo Caccialanza as Signor Ramondi (uncredited)

Jimmy Federico as Dancer (uncredited)

Danielle Franke as Gucci Salesgirl (uncredited)

Jennifer Diane Hanson as Bridesmaid (uncredited)

Charles M. Kerper as Talk Show PA (uncredited)

Mike Kirkland as Young TV Executive (uncredited)

Michael Nardelli as Party Guest (uncredited)

Tyson Power as Father Tyson (uncredited)

Wendy Rodriguez as Bridesmaid (uncredited)

Aaron Stephens as Kevin's Friend (uncredited)

Kellee Stewart as Make-Up Girl (uncredited)

Gian Franco Tordi as Italian Waiter (uncredited)

Amanda Wyss as Tina Gray (archive footage) (uncredited)

Nina Xining Zuo as Bellhop Girl (uncredited)