Joaquin Phoenix as Joaquin Phoenix

Antony Langdon as Anton

Carey Perloff as Play Director

Larry McHale as Larry McHale

Casey Affleck as Casey Affleck

Jack Nicholson as Jack Nicholson

Billy Crystal as Billy Crystal

Danny Glover as Danny Glover

Bruce Willis as Self - Guest

Robin Wright as Robin Wright

Johnny Moreno as Victor - Danny DeVito's Stand-In

Danny DeVito as Danny DeVito

Jerry Penacoli as Jerry Penacoli

Susan Patricola as Susan Patricola

Patrick Whitesell as Patrick Whitesell

Nicole Acacio as Nicole Acacio

Matthew Maher as Matt Maher

Amanda Scheer-Demme as Amanda Demme

Josie as Josie

Carline as Capricorn Clark (voice)

Yasiin Bey as Mos Def

Christine Spines as Christine Spines

David Grutman as David Grutman

Sean Combs as Sean Combs

Jamie Foxx as Jamie Foxx

Ben Stiller as Ben Stiller

Norm Block as Norm Block

Mike Snedegar as Lavo Event Host

Edward James Olmos as Edward James Olmos

David Letterman as David Letterman

Natalie Portman as Natalie Portman

Eddie Rouse as Miami Heckler

Jamison Reeves as Miami Heckler

Elliot Gaynon as Hollywood Eddie

Tim Affleck as Joaquin's Father

Alec Baldwin as Self (archive footage) (uncredited)

Peter Coffin as Announcer / Joaquin (uncredited)

Steve Coogan as Self (archive footage) (uncredited)

Nathan Lane as Nathan Lane (uncredited)

Jay Leno as Jay Leno (uncredited)

Olivia Munn as Self (archive footage) (uncredited)

Conan O'Brien as Conan O'Brien (archive footage) (uncredited)

Barack Obama as Self (archive footage) (uncredited)

Ashley Olsen as Ashley Olsen (uncredited)

Sean Penn as Sean Penn (uncredited)

Regis Philbin as Regis Philbin (uncredited)

Kelly Ripa as Kelly Ripa (uncredited)

Britney Spears as Self (archive footage) (uncredited)

John Travolta as Self (archive footage) (uncredited)

Cenk Uygur as Self (archive footage) (uncredited)