John C. Reilly as Eli Sisters

Joaquin Phoenix as Charlie Sisters

Jake Gyllenhaal as John Morris

Riz Ahmed as Hermann Kermit Warm

Rebecca Root as Mayfield

Allison Tolman as Girl Mayfield Saloon

Rutger Hauer as The Commodore

Carol Kane as Mrs Sisters

Patrice Cossonneau as Blount

Zac Abbott as Blount Guy Dying

David Gasman as Relay Owner

Philip Rosch as Storekeeper Pioneer Town 2

Creed Bratton as Quarrel Saloon Guy Town 02

Lenuta Bala as Woman with the Bortsch

Jochen Hägele as Horse Dealer Town 03

Eric Colvin as Horse Dealer Relay 02

Ian Reddington as The Father

Aldo Maland as Young Eli

Theo Exarchopoulos as Young Charlie

Sean Duggan as Jacksonville House Keeper

Raymond Waring as Mayfield Bartender

Jóhannes Haukur Jóhannesson as Head Trapper

Gerard Cooke as Storekeeper Mayfield

Frédéric Siuen as Pacific Chinese Dad Prospector

Trevor Allan Davies as Golden Pearl Valet

Aidan O'Hare as Horse Dealer American River

Andrew Litvack as Prospector

Nick Cornwall as Man Encampment Attacker 1

Duncan Lacroix as Man Encampment Attacker 2

Jean-Marc Bellu as Man Encampment Attacker 3

Diego Llano as American River Indian

Hugo Dillon as Dr Crane

Lexie Benbow-Hart as Dr Crane’s Daughter

Richard Brake as Rex

Kelda Holmes as Poor Woman Commodore