Claudette Colbert as Elizabeth Hamilton

Orson Welles as John Andrew MacDonald

George Brent as Lawrence Hamilton

Lucile Watson as Aunt Jessica Hamilton

Richard Long as Drew Hamilton

Natalie Wood as Margaret Ludwig

John Wengraf as Dr. Ludwig

Sonny Howe as Brian Hamilton

Ian Wolfe as Norton

Joyce Mackenzie as Cherry Davis

Jesse Graves as Ambrose

Henry Hastings as Daniel

Boyd Irwin as Dr. Callan

Tom Wirick as Pudge Davis

Jack Cheatham as Policeman

Lois Austin as Woman

Charles D. Brown as Immigration Officer

Mike Donovan as Conductor

Jessica Grayson as Servant

Milton Kibbee as Baltimore Postman

Anne Loos as Freckled-Face Nurse

Thomas Louden as Englishman on Ship

Irving Pichel as Radio Commentator (Voice)

Gary Pietila as Baby Drew in Elizabeth's Lap

Douglas Wood as Charles Hamilton

Leonard Carey as Hamilton Employee

Jeffrey Sayre as Hamilton Employee

Lane Chandler as Hamilton Lab Technician

Lane Watson as Hamilton's Secretary

Sam Wren as Hamilton's Secretary

Libby Taylor as Hamilton's Maid

Betty Greco as Girlfriend

Barbara Bletcher as Girlfriend

Marguerite Campbell as Girlfriend

Helen Gerald as Girlfriend

Anne Howard as Girlfriend

Bobbie Brooks as Girlfriend

Nena Ruth as Girlfriend

Evan Thomas as Ship's Doctor

Carmen Beretta as Ship's Passenger

Carli Elinor as Ship's Passenger

Louis Lowy as Ship's Passenger

Charles H. Faber as Ship's Passenger

Rudolf Myzet as Ship's Passenger

Tina Menard as Ship's Passenger

Lala Detolly as Ship's Passenger

Loulette Sablon as Ship's Passenger

Catherine Savitsky as Ship's Passenger

Waclaw Rekwart as Ship's Passenger

Count Stefenelli as Ship's Passenger

Amzie Strickland as Ship's Passenger

Hilda Tanzler as Ship's Passenger

William Dyer Jr. as Fraternity Boy

Jack Lindquist as Fraternity Boy

Michael Sloane as Fraternity Boy

Frank Chalfant as Fraternity Boy

Buster Phelps as Fraternity Boy

Eugene Taylor as Fraternity Boy

Bob Tidwell as Fraternity Boy

Frank Wyrick as Fraternity Boy