James Franco as Aron Ralston

Kate Mara as Kristi Moore

Amber Tamblyn as Megan McBride

Clémence Poésy as Rana

Lizzy Caplan as Sonja Ralston

Kate Burton as Aron's Mom

Treat Williams as Aron's Dad

Sean Bott as Aron's Friend

Fenton Quinn as Blue John

John Lawrence as Brion

Pieter Jan Brugge as Eric Meijer

Rebecca C. Olson as Monique Meijer

Jeffrey Wood as Andy Meijer

Norman Lehnert as Dan

Darin Southam as Zach

Koleman Stinger as Aron Age 5

Bailee Michelle Johnson as Sonja Age 10

Parker Hadley as Aron Age 15

Peter Joshua Hull as Boy on Sofa

Terry S. Mercer as Helicopter Pilot

Xmas Lutu as Helicopter Co-Pilot

Luke Drake as Aron's Friend (uncredited)

Robert Bear as Aron's Friend (uncredited)

Brad Johnson as Aron's Friend (uncredited)

Stacey Ann Turner as Aron's Friend (uncredited)

Zachary Haycock as Reporter (uncredited)

Lonzo Liggins as Reporter (uncredited)

Samantha Marsden as Media Person / Basketball Game Fan (uncredited)

Johnny Ahn as Basketball Fan (uncredited)

Christopher K. Hagadone as Basketball Fan (uncredited)

Kelsie Mathews as Basketball Fan (uncredited)

Amy Savannah as Basketball Fan (uncredited)

Adam Colvin as Summer Party Man (uncredited)

Elizabeth Hales as Patron (uncredited)

Kelly Higgins as Fan (uncredited)

Aron Ralston as Self (uncredited)

Jessica Ralston as Self (uncredited)

Kyle Paul as Best Man (uncredited)

Priscilla Poland as Bridesmaid (uncredited)