Joaquin Phoenix as John Callahan

Jonah Hill as Donny

Rooney Mara as Annu

Jack Black as Dexter

Tony Greenhand as Tim

Beth Ditto as Reba

Mark Webber as Mike

Ronnie Adrian as Martingale

Kim Gordon as Corky

Udo Kier as Hans

Carrie Brownstein as Suzanne

Ethan Tindukasiri as Skateboarder #1

Sunny Suljic as Skateboarder #2

Cree Kawa as Skateboarder #3

Nolan Gross as Skateboarder #4

Leo Phoenix as Skateboarder #5

Emilio Rivera as Jesus Alvarado

Ken Tatafu as Bill in Wheelchair

Angelique Rivera as Terry Alvarado

Rebecca Rittenhouse as Bonnie

Anne Lane as Virginia

Jessica Jade Andres as Cindy

Torian Miller as Car Attendant

Rebecca Field as Margie Bighew

Olivia Hamilton as Nurse Lilly

Peter Banifaz as Doctor Mirione

Alexandra W.B. Malick as Older Nurse

Kyle Dunnigan as Ward Doctor

Santina Muha as Debbie

Daniella Garcia as Nurse at Rancho Hospital

Christopher Thornton as Charles-Marie

Edgar Momplaisir as Roger Fairies

Matt Bennett as Editor #2

Joe Baken as Editor #3

Ron Perkins as Mr. Katz

Heather Matarazzo as Shannon

Michael Chow as PSU Teacher

Ryan Meharry as Police Office #1

Cathy Fielding as Bakery Woman

John Bishop as Cowboy Wino

Ronnie Clark as Wino One

Jonathan Erickson Eisley as Junior Wino

Betsy Sodaro as Powell's Information Person

Jedediah Jones as Felix - AA Member #1

Lou Wilson as Joseph - AA Member #2

John Balma as Department Store Man

Ayden Mayeri as Brenda

Nick Rutherford as Drinker

Ramy Youssef as Drinker

Robby Rasmussen as Levon - Man on Bike

Maxwele D'Angelo as Cabbie

Helen Slayton-Hughes as Woman on Bus

Bruce Richmond Chambers as School Teacher

Ethan Michael Mora as Young John Callahan

Kade Martinez as Young John's Brother #1

Brady Nuthall as Young John's Brother #2

Isabella Baltodano as Young John's Sister

Mireille Enos as John's Ghost Mom

Erica Jade Goldsmith as Cocktail Waitress

Suzy Sincock as Liquor Store Owner

Connor Skific as Cowboy

Sheila Brown as Rancho Therapist

Jeffrey Gamble as John's Roommate - Jesus

Scott Alan Berk as Police Officer #2

Patricia Widuch as Long Beach Nurse

Dion Earl as Physical Therapist

Jim Kwiatkowski as Orderly

Kelli McNeil-Yellen as Woman with Dog

Gus Van Sant as Willamette Week Editor

Steve Zissis as Elias (uncredited)

Jaret Martino as Booth Operator (uncredited)