Oscar Isaac as Will Dempsey

Olivia Wilde as Abby Dempsey

Annette Bening as Dr. Cait Morris

Antonio Banderas as Vincent Saccione

Samuel L. Jackson as Self

Olivia Cooke as Dylan Dempsey

Mandy Patinkin as Irwin Dempsey

Jean Smart as Linda Dempsey

Sergio Peris-Mencheta as Javier González

Laia Costa as Isabel Díaz

Àlex Monner as Rodrigo González Díaz

Isabel Durant as Shari Dickstein

Lorenza Izzo as Elena Dempsey-González

Jake Robinson as Henry / Hero

Adrián Marrero as Rodrigo (7-10 Years Old)

Kya Kruse as Young Dylan

Charlie Thurston as Jack

Gabby Bryan as Elizabeth

Jordana Rose as Abby (5-7 Years Old)

Caitlin Carmichael as Abby (11-13 Years Old)

Bryant Carroll as Uncle Joe

Carmela Lloret as Rodrigo's Therapist

Grace Song as Female Barista

Micah Stock as Barista

Tony Manna as Manager

Yvonne Szacki as Vet

Noah Gaynor as Hot Frat Guy

Ed Crescimanni as Therapist #4

Zach Page as Bandmember

Brian Deodat as Bandmember #2

Joe Apollonio as Drunk at Bar #1

Mikaela Steele as Bar Patron

Manuel Ramos Morilla as Laborer

María Dolores Rodríguez Villegas as Flower Seller

Carmen Vique Rodríguez as Beautiful Woman

David Freedman as Magician

Theodore Mejia as Spanish Speaking Tourist #1

Caridad Montanez as Spanish Speaking Tourist #2

Javier Verdugo Luque as Rodrigo (10 yrs)

Pablo Lagüens Abad as Rodrigo (13 yrs)

Yeray Alba León as Rodrigo (14 yrs)

Rehan as Doctor

Dale Nussbaum as Professor

María Dolores López Vera as Nurse