Simon Amstell as Narrator

Linda Bassett as Dr Yasmine Vondenburg

Martin Freeman as Jeff

Eileen Atkins as Dorothy

Joanna Lumley as Herself (voice)

Lindsay Duncan as Maude

Alex Lawther as Volunteer: Joey

Gemma Jones as Davina

John Macmillan as Troye King Jones

Claire Keelan as Lindsay Graber

James Smith as Graham Watkins

Samantha Spiro as Edith Paper

Martin Sims as Prof. Charles Grandage

Simon Chandler as Barnaby Jones

Michael Fenton Stevens as Peter Smithball

Jumayn Hunter as Robert

Simon Fisher-Becker as Kevin

Collette Cooper as Georgina

Andy Rush as Mike

Roy Sampson as Leon

George Keywood as Larry

Vanessa Earl as Lisa Thomas

Scott Chambers as Kyle

Earth-G as Fred

Will Rastall as Bertie

James Bloor as Vegan

Josephine Butler as Teacher

Matthew Beard as Jeremy (voice)

Karl Theobald as Daddy (voice)

Margaret Clunie as Model

Mawaan Rizwan as Freddy Javashankar

Robert Cawsey as Confused Man

Natalie Jones as Confused Woman

Kirsty Wark as Herself

Lorraine Kelly as Herself

Vanessa Feltz as Herself

Clive Myrie as Himself

Racheal Ofori as Patricia

Jamie Adenuga as Himself