Rebel Wilson as Natalie

Liam Hemsworth as Blake

Adam Devine as Josh

Priyanka Chopra Jonas as Isabella

Betty Gilpin as Whitney

Brandon Scott Jones as Donny

Tom Ellis as Dr. Todd

Jennifer Saunders as Natalie's Mother

Jay Oakerson as Gary

Michelle Buteau as Martina

Alex Kis as 12 Year Old Natalie

Rao Rampilla as Food Cart Man

Marcus Choi as Cute Guy

Hugh Sheridan as Cute Guy

Luciano Acuna Jr. as Cute Guy

Raymond Anthony Thomas as Boss

Zach Cherry as Co-Worker

Sandy Honig as Co-Worker

Rosemary Howard as Co-Worker

Ron Nakahara as Co-Worker

Shyrley Rodriguez as Young Girl

Dean Neistat as Bearded Guy

Trevor Kuhn as Dog Walker

Lorrie Odom as MTA Worker

Joe Towne as Normal Dude (Rich)

Joseph R. Sicari as Giovanni

Shonali Bhowmik as Bridesmaid

Sawandi Wilson as Hot Doctor

Seth Barrish as Haggard Doctor

Bowen Yang as Donny's Guy

Alana Da Fonseca as Nacho Girl

Esteban Benito as Officer Handsome

Brandon Block as Dancer

Marija Abney as Dancer

Eugenia Kuzmina as Fashion Model (uncredited)

Doris McCarthy as Homeless Lady (uncredited)

Jacqueline Honulik as Bridesmaid (uncredited)

Stacey Alyse Cohen as RomCom Neighbor (uncredited)

Marmee Regine Cosico as SAG Pedestrian (uncredited)

Thomas Canestraro as Officer Trombetta (uncredited)

Leonard Zimmerman as Romantic CP Rower (uncredited)

Hunter Clowdus as Harry - Wedding Guest (uncredited)