Charlie Sheen as Jeffrey Cage

Whoopi Goldberg as Metzie

Luis Guzmán as Eddie

Gina Gershon as Eve

Wood Harris as Michael

Bruce Davison as Monohan

Dahlia Waingort as Lisa

Faune Chambers Watkins as Holly

Matt Lauer as Himself

Olga Fonda as Tina

Ian Fisher as Fireman

Jacqueline Bisset as Diane

Billy Malone as Anderson

Katie Couric as Herself

Ryan R. Johnson as Firefighter

Whitney Avalon as Nicki

April Betts as Waitress

Brian J. Singer as Frankie

Prestyn Bates as J.J.

James Quattrochi as Captain

Dave Cobert as Chief

Mandell Frazier as Paramedic

Nick Stellate as Firefighter

Matt Laydon as Commuter

Johnny Colon as Lopez

Sterling Fitzgerald as Executive

Paul David Roberts as Technician

Punnavith Koy as

George W. Bush as Self (archive footage) (uncredited)