James D'Arcy as Sherlock Holmes

Roger Morlidge as Dr. Watson

Vincent D'Onofrio as Moriarty

Gabrielle Anwar as Rebecca Doyle

Richard E. Grant as Mycroft

Nicholas Gecks as Inspector Lestrade

Struan Rodger as Ben Harrington

Peter-Hugo Daly as Henry Coot

Mihai Bisericanu as Sgt. Cox

Sandu Mihai Gruia as Dr. Cruickshank

Constantin Bărbulescu as Captor #1

Doru Dumitrescu as Captor #2

Natalie Ester as Pretty Young Hopeful

Ioana Abur as Victoria

Fritha Goodey as Anna

Valentin Popescu as Killer

Anca Androne as Nurse