Melissa McCarthy as Lilly Maynard

Chris O'Dowd as Jack Maynard

Kevin Kline as Dr. Larry Fine

Timothy Olyphant as Travis Delp

Daveed Diggs as Ben

Skyler Gisondo as Dickey

Laura Harrier as Sherri

Kimberly Quinn as Regina

Loretta Devine as Velma

Jesse García as Hector

Edi Patterson as Margie

Emily Tremaine as Alice

Rosalind Chao as Fawn

Ravi Kapoor as Dr. Manmohan

Don McManus as Big Daddy

Owen Atlas as Howie