Paul Giamatti as Barney Panofsky

Dustin Hoffman as Izzy Panofsky

Rosamund Pike as Miriam Grant-Panofsky

Minnie Driver as The 2nd Mrs. P

Scott Speedman as Boogie

Rachelle Lefevre as Clara 'Chambers' Charnofsky

Bruce Greenwood as Blair

Mark Addy as Detective O'Hearne

Macha Grenon as Solange

Jake Hoffman as Michael Panofsky

Anna Hopkins as Kate Panofsky

Saul Rubinek as Charnofsky

Harvey Atkin as 2nd Mrs. P's Father

Linda Sorensen as 2nd Mrs. P's Mother

Brittany Drisdelle as Girl at Cafe

Thomas Trabacchi as Leo

Clé Bennett as Cedric

Paul Gross as Constable O'Malley of the North

Maury Chaykin as Wedding Guest

Larry Day as Bartender at Wedding

Mark Camacho as T / U Productions Executive #1

Harry Strandjofski as Dr. Morty

Atom Egoyan as O'Malley Director #1

David Cronenberg as O'Malley Director #2

Ted Kotcheff as Train Conductor

David Pryde as T / U Productions Executive #1

Paula Jean Hixson as Bartender at Grumpy's

Marica Pellegrinelli as The Countess

Domenico Minutoli as Judge at Rome Wedding

Massimo Wertmüller as Rome Doctor

Howard Jerome as Uncle Irv

Sam Stone as Fundraising Target #1

Burney Lieberman as Fundraising Target #2

Morty Bercovitch as Fundraising Target #3

Pauline Little as The 2nd Mrs. P's Housekeeper

Robin Kazdan as Wedding Guest

Len Richman as Rabbi

Sheila Hymans as Rabbi's Wife

Kyle Switzer as Production Assistant

Rebecca Croll as Receptionist #1

Steve Bienstock as NY Restaurant Waiter

Arthur Holden as Notary

Zack Kifell as Young Michael Panofsky

Simone Richler as Young Kate Panofsky

Denys Arcand as Maitre'D at Ritz

Arthur Grosser as Mr. Dalhousie

Pascale Bourbeau as Woman at Cemetery

Ellen David as Massage Parlour Madame

Katia Di Perna as Masseuse

Marina Eva as Leo's Girlfriend

Sandra Lavoie as Barney's One Night Stand

Ivana Shein as Receptionist #2

Mélanie St-Pierre as O'Malley's New Co-Star

Tarah Schwartz as Reporter

Richard J. Lewis as Pathologist

Howard Rosenstein as Cousin Jeff