Kyrie Irving as Uncle Drew

Lil Rel Howery as Dax Winslow

Shaquille O'Neal as Big Fella

Chris Webber as Preacher

Reggie Miller as Lights

Nate Robinson as Boots

Lisa Leslie as Betty Lou

Erica Ash as Maya

JB Smoove as Angelo

Mike Epps as Louis

Tiffany Haddish as Jess

Nick Kroll as Mookie Bass

Ashton Tyler as Young Dax

Aaron Gordon as Casper Jones

Wesley Witherspoon as Mario

Barry Rohrssen as Referee

Selema Masekela as

John Calipari as

Jon Hammond as

Scoop Jackson as

Pee Wee Kirkland as

Earl Monroe as

Chris Mullin as

Bill Walton as Self

George Gervin as

Steve Nash as

David Robinson as Self

Jerry West as

Dikembe Mutombo as Self

NeNe Leakes as

Rick Barry as

Rick Ross as

Scott Van Pelt as

Ben Nethongkome as

Crystal Lee Brown as Mom

Jamel Chambers as Angry Fan

Terence Rosemore as Customer #1

Gage Lawson as Teen Playing Basketball (uncredited)

Alannah Wilhite as Girl in club

Deadra Moore as Desk Nurse

Tinuke Adetunji as Angelo's Girl