Kyrie Irving as Uncle Drew

Lil Rel Howery as Dax Winslow

Shaquille O'Neal as Big Fella

Chris Webber as Preacher

Reggie Miller as Lights

Nate Robinson as Boots

Lisa Leslie as Betty Lou

Erica Ash as Maya

Tiffany Haddish as Jess

Nick Kroll as Mookie Bass

Aaron Gordon as Casper Jones

Mike Epps as Louis

JB Smoove as Angelo

Wesley Witherspoon as Mario

Thomas Mills as Duke Tango

Selema Masekela as Sal Masekela

Adam Lazarre-White as Frankie the Tournament Director / Narrator

Lavar Walker as Marty the Manager

John Calipari as John Calipari

Joe Hammond as Joe Hammond

Scoop Jackson as Scoop Jackson

Pee Wee Kirkland as Pee Wee Kirkland

Earl Monroe as Earl Monroe

Chris Mullin as Chris Mullin

Maurice G. Smith as Dominic 'The Glove' Willis

Kevin Benton as Zeke 'The Mouth' Murray

Bill Walton as Bill Walton

George Gervin as George Gervin

Steve Nash as Steve Nash

David Robinson as David Robinson

Jerry West as Jerry West

Rick Barry as Rick Barry

Dikembe Mutombo as Dikembe Mutombo

NeNe Leakes as Nene Leakes

Aiden Williams as Adopted Kid

Tinuke Adetunji as Angelo's Girl

Deadra Moore as Desk Nurse

Enoch King as Baby's Dad

Crystal Lee Brown as Mom

Kenneth Crudup as Baller

Mark Robert Ellis as Basketball Coach (as Mark Ellis)

Terence Rosemore as Customer #1

Terrence 'T.C.' Carson as Customer #2

Rick Ross as Customer #3

Trey Griffith as Dax - 4 Years Old

Judah Howery as Dax - 10 Years Old

Ashton Tyler as Young Dax

Carrie Walrond Hood as Foot Locker Mother

Lorenzo Davis as Opponent

Brian Kortovich as Opponent

Keith Jamal Evans as Other Kid (as Keith Evans)

Josh Henry as Paramedic

Phil Ductan as Player

Elijah Everett as Player

Rocco Poveromo as Referee

Barry Rohrssen as Referee

Scott Van Pelt as Scott Van Pelt - ESPN Host (uncredited)

Jamel Chambers as Angry Fan

Alannah Wilhite as Girl in club

Matt McHugh as Security Guard

Dario A. Lee as The Destroyer (uncredited)