Matt Dillon as Bob

Kelly Lynch as Dianne

James Remar as Gentry

James Le Gros as Rick

Heather Graham as Nadine

Beah Richards as Drug Counselor

Grace Zabriskie as Bob's Mother

Max Perlich as David

William S. Burroughs as Tom the Priest

Eric Hull as Druggist

John Kelly as Cop

George Catalano as Trousinski

Janet Baumhover as Neighbor Lady

Ted D'Arms as Neighbor Man

Neal Thomas as Halamer

Stephen Rutledge as Hotel Manager

Robert Lee Pitchlynn as Hotel Clerk

Roger Hancock as Machinist

Michael Parker as Crying Boy

Ray Monge as Accomplice

Gus Van Sant as Himself (uncredited)