Sean Young as Dr. Stephanie Brody

Michael McKean as Dr. Simon August

Gary Friedkin as Dr. Milton Chamberlain

Kyle T. Heffner as Dr. Charles Litto

Rick Overton as Dr. Thurman Flicker

Crystal Bernard as Julie

Ted McGinley as Dr. Bucky DeVol

Saul Rubinek as Floyd Kurtzman

Harry Dean Stanton as Dr. Oliver Ludwig

Patrick Macnee as Jacob

Dabney Coleman as Dr. Joseph Prang

Héctor Elizondo as Angelo / Angela Bonafetti

Peggy Trentini as The Others - Christmas Elf

Pamela Reed as Nurse Norine Sprockett

Taylor Negron as Dr. Phil Burns

Patrick Collins as Dr. Walter Rist

Michael Richards as Malamud Callahan

Titos Vandis as Sal Bonafetti

Richard Dean Anderson as Drug dealer

Monique Gabrielle as (uncredited)

Haunani Minn as The Nurses - Chang

Becky Gonzalez as The Nurses - Perez

Lynne Marie Stewart as The Nurses - Thatcher

Toni Hudson as The Candystripers - Bunny

Frank Pesce as The Gangsters - Rocco

Nicholas Mele as The Gangsters - Jerry

Michael Damian as Soap Cameos

Steven Ford as Soap Cameos

Stuart Damon as Soap Cameos

Jaime Lyn Bauer as Soap Cameos

Tom Ligon as Soap Cameos

Kin Shriner as Soap Cameos

Janine Turner as Soap Cameos

Jacklyn Zeman as Soap Cameos

Diane Markoff as The Cops - Emilia

Walter Scott as The Cops - Bed Mechanic

Reynaldo Rey as The Cops - Cicerelli

Billie Bird as The Hospital Staff - Flower Lady

Millee Taggart as The Hospital Staff - Miss Ditka

Larry Jenkins as The Hospital Staff - Paul the Orderly

Stuart Charno as The Hospital Staff - Warren the Orderly

John Steadman as The Patients - 82 Year Old Man

Scott Marshall as The Patients - Boy with Fly

George Furth as The Patients - Disgusting Looking Patient

Ed Begley Jr. as The Flashback - Young Simon's Father

Michael Elias as The Others - Spectator

Kimberly McArthur as The Candystripers - Jyll Omato

Rose Michtom as The Others - Mrs. Pierce

Paul Stanley as Self (scenes deleted)

Cynthia Geary as Girl with Broken Nose (uncredited)

Susan Lucci as Susan Lucci (uncredited)

John E. Coleman as Featured (uncredited)

Demi Moore as New Intern (uncredited)

Hillary Horan as The Nurses - Theresa