Lou Gehrig as Self (archive footage)

Babe Ruth as Self (archive footage)

Kirk Gibson as Self (archive footage)

Bob Costas as Self

Bob Uecker as Self

Joe Buck as Self

Charissa Thompson as Self

Wade Boggs as Self

Jose Canseco as Self

Steve Sax as Self

Jim Cramer as Self

George Will as Self

John Thorn as Self

Tony Suck as Self (archive footage)

Mehmet Oz as Self

Tim Gunn as Self

Don Mattingly as Self

Ezra Klein as Self

Bill de Blasio as Self

Mike Scioscia as Self

Drew Pinsky as Self

Ken Griffey Jr. as Self

Russell Brand as Self

Ozzie Smith as Self

Neil deGrasse Tyson as Self

Aaron Judge as Self

Roger Clemens as Self

Al Jean as Self

Nick Offerman as Brad Pitt / George W. Bush / John Swartzwelder

Hank Azaria as Carl / Umpire / Wiggum / Moe / Apu (voice)

Dan Castellaneta as Homer Simpson / Aristotle Amadopolis (voice)

Bill Clinton as Self (archive footage)

Ty Cobb as Self (archive footage)

Joe Jackson as Self (archive footage)

David Kaye as Self - Narrator

MC Hammer as Self (archive footage)

Tress MacNeille as Shelby (voice)

Maggie Roswell as Nurse / Distressed Woman (voice)

Harry Shearer as Jebediah Springfield / Lenny Leonard / Mr. Burns (voice)

Jerry Springer as Self (archive footage)

Morgan Spurlock as Self - Narrator

Buck Weaver as Self (archive footage)