Michael Caine as Dr. Henry Jekyll / Mr. Edward Hyde

Cheryl Ladd as Sara Crawford

Joss Ackland as Dr. Charles Lanyon

Ronald Pickup as Jeffrey Utterson, Esquire

Diane Keen as Annabel

Kim Thomson as Lucy Harris

Kevin McNally as Sergeant Hornby

David Schofield as Snape

Lionel Jeffries as Jekyll's Father

Lee Montague as Inspector Palmer

Miriam Karlin as Mrs. Hackett

Lance Percival as Beresford Mount, Prince's Private Secretary

Joan Heal as Mrs. Clark

Frank Barrie as Poole the Butler

Martin Jacobs as Young Man (as Martyn Jacobs)

Duncan Gould as Businessman

John Scarborough as Auctioneer

Harvey Ashby as Customer

Ray Armstrong as Head Groom

Kiran Shah as Sara's Son

Nina Kennedy as Little Girl

Peter Gale as Lanyon's Butler

Andrew Castell as Dr. Lloyd

Gary Shail as Sailor

David Michaels as Medical Student 1

Simon Adams as Medical Student 2

Richard Dixon as Medical Student 3

Eric Dodson as Head Porter

Jill Pearson as Nurse

Samantha Womack as Young Maid (Margaret) (as Samantha Janus)

Margaret Rawlings as Jekyll's Mother

Michael Stainton as Duty Sergeant

Jazzer Jeyes as Pub Customer

Terry Walsh as Pub Customer

Eric Mason as Landlord

Philip Locke as Editor

Terence Plummer as Big Detective

Ross McCall as Copy Boy

Peter Geeves as Sub Editor

Craig Crosbie as Lab Technician

Antony Brown as Sergeant Cop

Nigel Betts as Local Cop

Prentis Hancock as Vendor/Detective