Melissa McCarthy as Kathy Brennan

Tiffany Haddish as Ruby O'Carroll

Elisabeth Moss as Claire Walsh

Domhnall Gleeson as Gabriel O'Malley

Bill Camp as Alfonso Coretti

Margo Martindale as Helen O'Carroll

Common as Gary Silvers

James Badge Dale as Kevin O'Carroll

Brian d'Arcy James as Jimmy Brennan

Jeremy Bobb as Rob Walsh

E.J. Bonilla as Gonzalo Martinez

Wayne Duvall as Larry - Kathy's Father

Annabella Sciorra as Maria Coretti

Myk Watford as Little Jackie Quinn

Pamela Dunlap as Mary - Kathy's Mother

John Sharian as Duffy

Brian Tarantina as Burns

Will Swenson as Michael Mariano

Bernie McInerney as Paul Hogan

Sharon Washington as Estelle

Matt Helm as Colin

Angus O'Brien as Mark Williams

Ciarán O'Reilly as Owen Gibson

Nicholas Zoto as Peter Brennan

Maren Heary as Jennifer Brennan

Stephen Singer as Herb Kanfer

Tatienne Hendricks-Tellefsen as Rachel Kanfer

Jordan Gelber as Chaim

Brandon Uranowitz as Shmuli Chudakoff

Bernie Rachelle as Fyvish Wainer

Tina Benko as Donna - Nail Salon Owner

Susan Blommaert as Mrs. Sullivan

George Riddle as Mr. Sullivan

Tom Patrick Stephens as Father Monaghan

Ann McDonough as Church Nun

Joseph Russo as Greek Tony

Louis Vanaria as Enzo - Goon #1

James Ciccone as Joe - Goon #2

Aaron Berg as Sal - Goon #3

Jonathan Eddy Duran as Raul the Pimp

Lenny Venito as Officer Ritchie MacLeod

Kevin Nagle as Officer Lancer

Shaun O'Hagan as Officer Berlinski

Marquise Vilson as Court Officer

Daniel O'Shea as Union Head

Adam Mucci as Union Construction Worker

Jamie Jackson as Union Construction Worker

Brendan Burke as Union Hall Bartender

Dan Daily as Union Member Scotty

Rob Yang as Jeffrey Kahn

Matthew Boston as FBI Boss

Lynn Spencer as Galaxy Diner Waitress

Linda Marie Larson as Mrs. Morris

Gabriel Rush as Claire's Landlord's Kid

Adina Verson as Prostitute

Ashley Perez Flanagan as Prostitute

Manny Ureña as Gross Guy Stranger

Ethan Dubin as Loser Guy on 42nd Street

Ava Eisenson as Screaming Woman

Brian Charles Johnson as Giovani - The Butcher

Jack Lynch as Scrawny Kid

Vaughn Lynch as Scrawny Kid

Tommy Buck as Clothing Store Owner

Loic Mabanza as Dancing Hunk

Alexis Roberts as Dancer

Shernita Anderson as Dancer

Lily Davis as Dancer

Joaquim de Santana as Dancer

Christine Sienicki as Dancer

Jonathan Royse Windham as Dancer

Borris Anthony York as Dancer

Marla Phelan as Dancer

Kellie Drobnick as Dancer

Sabrina Imamura as Dancer

Deva Huggins as Dancer

Brandon Rubendall as Dancer

Keith Kuhl as Dancer

Mason Henry as Boy (uncredited)