T-Pain as Freaknik (voice)

Joey Galaxy as Virgil (voice)

Cee Lo Green as Lite Skinn'd (voice)

Rick Ross as Big Uzi (voice)

DJ Pooh as Doela Man (voice)

Lil Jon as Foreboding Old Dude (voice)

Big Boi as Preacher (voice)

DJ Drama as Mr. Thanksgiving (voice)

Snoop Dogg as Gang Member (voice)

Kelis as (voice)

Mack Maine as (voice)

Sophia Fresh as Leacosia / Toprameneesha / Obamaniqua / Suzie (voice)

Lil Wayne as Trap Jesus (voice)

Charlie Murphy as (voice)

Bill Hader as Tad (voice)

Andy Samberg as Chad (voice)

George Clinton as (voice)

Bootsy Collins as (voice)

Kel Mitchell as Fruit Bowl Boys Leader (voice)

Liz Benoit as Oprah Winfrey (voice)

Gene Anderson as (voice)

Reginald Boyland as (voice)

Christopher Reid as (voice)

Christopher Martin as (voice)

Affion Crockett as (voice)

Corey Burton as (voice)

Carl Jones as Virgil's Boss (voice)

Heather Lawless as (voice)