Adam Beach as Johnny

Tantoo Cardinal as Auntie Apple

Bradley Cooper as Luke

Glen Gould as Steve Klamath

Dan Harrison as Walter Many Lightnings

Sarah Agnew as Mary

Wes Studi as Richard Two Rivers

Chris Mulkey as Paul Gunderson

Georgina Lightning as Rain

Stephen Yoakam as Father Bartoli

Mark Benninghoffen as BIA Official Bryan Walker

Joe App as Boarding School Priest

Jeri Arredondo as Young Adult Irene

Noah Kol Balfour as Little Many Lightnings

Dennis Banks as Pete Goodfeather

Raven Bellefleur as Little Irene

Rose Berens as Irene

Jennifer Blagen as Clerk

Dale R. Botten as Priest with Young Boy

Chris Carlson as Redneck

Deborah Collins as Mom at Bingo Hall

Debbie DeLisi as Penmore Receptionist

Faryn DuPuis as Bruised Girl

Ray Early as Vet #1

Bill Effinger as Government Official

Michael Egan as Guy in Crowd

Gloria May Eshkibok as Mattie Moonshadow

Tony Flores as Native Nurse (Tony)

James Gaulke as Uniformed Guard

Greg Hallback as Grave Digger #1

Maile'ana Kanewa as Little Apple

Barbara Kingsley as Librarian

Drew Lacafa as Joking Vet

Cody Lightning as Suicide Victim

Crystle Lightning as Diane

Zach Mitteness as Guy at Campfire

Jim Northrup as Jim

Tony Papenfuss as Dr. Herlihy

Penny Perry as Boarding School Nun

Mary Rehbein as White Woman

Jaylee Sayers as Native Indian Child

Garth Schumacher as Male Nurse

James Singleton as Uniformed Guard #2

Perry Skinaway as BIA Killer

Eleanor Smith as Native Indian Mother

Jason Stoiber as Grave Digger #2

Jacob Tewawina as Jacob

Arne Vainio as Guy Outside of Bar

Jordan Diver as Spirit Child

Makialani Kanewa as Spirit Child

Taleah King as Spirit Child

Winter Mayorga as Spirit Child

Kobe Nabors as Spirit Child

Toby Smith as Spirit Child

Simon Councillor as Boarding School Child

Kelsey Diver as Boarding School Child

Cole Hilton as Boarding School Child

Kayla Jackson as Boarding School Child

Whitney Mayorga as Boarding School Child

Anthony Moose as Boarding School Child

Cedar E. Savage as Boarding School Child

Tayden Thompson as Boarding School Child

Glenda Valdez as Boarding School Child

Michelle O'Neill as Basement Nun