Denzel Washington as Frank Lucas

Russell Crowe as Richie Roberts

Josh Brolin as Detective Trupo

Chiwetel Ejiofor as Huey Lucas

Cuba Gooding Jr. as Nicky Barnes

Lymari Nadal as Eva

Ted Levine as Lou Toback

Armand Assante as Dominic Cattano

John Ortiz as Javier J. Rivera

John Hawkes as Freddie Spearman

RZA as Moses Jones

Yul Vazquez as Alfonso Abruzzo

Ruby Dee as Mama Lucas

Idris Elba as Tango

Carla Gugino as Laurie Roberts

Joe Morton as Charlie Williams

Common as Turner Lucas

Ritchie Coster as Joey Sadano

Jon Polito as Rossi

Kevin Corrigan as Campizi

Roger Guenveur Smith as Nate

Malcolm Goodwin as Jimmy Zee

Ric Young as Chinese General

Roger Bart as US Attorney

T.I. as Stevie Lucas

KaDee Strickland as Richie's Attorney

Ruben Santiago-Hudson as Doc

Norman Reedus as Detective in Morgue

Kathleen Garrett as Mrs. Dominic Cattano

Albert Jones as Terrence Lucas

J. Kyle Manzay as Dexter Lucas

Melissia Hill as Redtop

Skyler Fortgang as Michael Roberts

Bari K. Willerford as Joe Louis

Warner Miller as Melvin Lucas

Quisha Saunders as Darlynn

Robert Funaro as McCann

Tom O'Rourke as Banker

Robert C. Kirk as Police Captain

Tom Stearns as 2-Star General

Jon DeVries as Judge James Racine

Jim R. Coleman as Bailiff

Lee Shepherd as Laurie's Attorney

Gavin Grazer as Mike Sobota

Linda Powell as Social Worker

Roxanne Amandez as Paramedic

Pierra Francesca as Stewardess

Eddie Rouse as Detective at Party

Maryann Urbano as Real Estate Broker

Cedric Sanders as Serviceman in Cafe

Jason Veasey as Serviceman in Cafe

Roosevelt Davis as Army Captain

Eric Silver as White Kid

Saycon Sengbloh as Tango's Woman

Conor Romero as Tough Teenager

Daniel Hilt as Tough Teenager

Daniel Farcher as Tough Teenager

David Spearman as Civilian Cleaning Staff

Maurice Ballard as Civilian Cleaning Staff

Paul Doherty as Newscaster

William C. Tate as Baptist Minister

George Lee Miles as Frank's Lawyer

Jason Furlani as Bailiff

Chris McKinney as Reporter on TV

David Wayne Britton as Army Colonel

Tommy Guiffre as Medical Examiner

Laurence Lowry as Paramedic

Dan Moran as Army Captain

Marjorie Johnson as Charlene

Larry Mitchell as FBI Agent

Chuck Cooper as Private Doctor

Kevin Geer as Law School Professor

Chance Kelly as MP

Hamilton Clancy as Seller

Sam Freed as Judge

Joey Klein as Chemist

Scott Dillin as 4th Amigo

Anthony Hamilton as Funk Band Singer

Sarah Hudnut as Assistant Prosecutor

Jeff Greene as Metal Door Worker

Tyson Hall as Drug Dealer

Kirt Harding as Drug Dealer

Bryant Pearson as Drug Dealer

Al Santos as Mechanic

William Hudson as Dealer

Christopher A. Sawyer as Dealer

Dylan Gallagher as Casket Loader

Jehan-Pierre 'The Preacher' Vassau as Narc Officer

Dawn A. Douglas as Narc Officer

Robbie Neigeborn as Cop in Narc Headquarters

Clinton Lowe as Man Arrested in Elevator

Wilhelm Lewis as Head Wedding Photographer

James Hunter as Deacon

Neville White as Deacon

Lonnie Gaetano as Prison Guard

Jeff Mantel as Officer Walsh

Serena Joan Springle as The Proctor

Ron Piretti as Judge

Nino Del Buono as Announcer

Panama Redd as Policeman

Arthur M. Mercante as Referee

Fab 5 Freddy as Smalls Patron

Jonah Denizard as Store Manager

Steve McAuliff as Mounted Policeman

Bill Richards as Helicopter Pilot

Fatima Robinson as Dancer

Celestine Rae as Dancer

Monique Lea-Gall as Dancer

Shannon MacMillan as Dancer

Latonya Tolbert as Dancer

Cicily Daniels as Dancer

Sandra Park as Singer

Yuri Kamino-Fennell as Singer

Clarence Williams III as Bumpy Johnson (uncredited)

Brian Albanese as Spectator (uncredited)

Brian Keith Allen as Narc Squad Detective (uncredited)

Ephraim Benton as Thug #4 (uncredited)

Myo Campbell as Red Carpet Walker (uncredited)

John Cenatiempo as Cop #1 (uncredited)

J.W. Cortes as Narc Officer in Hallway (uncredited)

Cris D'Annunzio as Frank McNamara (uncredited)

Ernest Dancy as Hustler (uncredited)

Michael Den Dekker as Undercover Cop (uncredited)

Mark DiConzo as Soldier (uncredited)

Kevin van Doorslaer as Student (uncredited)

Monique Dupree as Club Dancer (uncredited)

Joseph Ferrante as Gangster at Funeral (uncredited)

Eddie Goines as Hallway Guy (uncredited)

Kelvin Hale as Drug room door security (uncredited)

Gabriel Hansen as Mechanic Drug Dealer (uncredited)

Jermel Howard as Kid gangster #1 (uncredited)

Hristo Hristov as Bookie / Soldier (uncredited)

Atif Lanier as Frank Lucas Bodyguard (uncredited)

Tina Lorraine as Harlem Junkie (uncredited)

Artie Pasquale as Mobster (uncredited)

Nick Poltoranin as Mobster (uncredited)

Kevin Pinassi as Building Maintenance Guy (uncredited)

Louis Rosario as Teenage Vandal (uncredited)

Paula Rittie as Maid of Honor (uncredited)

Billy Smith as Bookkeeper (uncredited)

Aija Terauda as Nicky's Girl (uncredited)

Tammy Vaughn as Diana Ross (uncredited)

Philippe Vonlanthen as Skeet Shoot Handler (uncredited)

Brad Lee Wind as Trupo's detective in library (uncredited)

Ray Wineteer as Photographer (uncredited)

Frances Mignano as Marie Saldano (uncredited)