Matthew Rhys as Lloyd Vogel

Tom Hanks as Fred Rogers

Chris Cooper as Jerry Vogel

Susan Kelechi Watson as Andrea Vogel

Maryann Plunkett as Joanne Rogers

Enrico Colantoni as Bill Isler

Wendy Makkena as Dorothy Vogel

Tammy Blanchard as Lorraine Vogel

Noah Harpster as Todd

Carmen Cusack as Margy Whitmer

Kelley Davis as First AD

Christine Lahti as Ellen

Maddie Corman as Betty Aberlin

Daniel Krell as Mr. McFeely

Jon L Peacock as Sound Technician

Gretchen Koerner as Doctor

Gavin Borders as Young Boy

Mark August as Young Boy's Dad

Tressa Glover as Young Boy's Mom

Jessica Hecht as Lila Vogel

Di Zhu as Waitress

Diane Monroe as Uptown String Quartet

Maxine Roach as Uptown String Quartet

Lesa Terry as Uptown String Quartet

Tahirah Whittington as Uptown String Quartet

Nigel Swinson as Subway Singer

Kayla Fan as Subway Singer

Alexander Ment as Subway Singer

Madeline Ment as Subway Singer

Olivia Irene Ruiz as Subway Singer

Kiesse Yengo-Passy as Subway Singer

Marcel Kottmann as Subway Singer

John Castagliola as Subway Singer

Preston Lopez as Subway Singer

Reginald Bannerman as Subway Singer

Spencer Lott as Puppeteer

Haley Jenkins as Puppeteer

Marc Petrosino as Puppeteer

Kathleen Kim as Puppeteer

Kathleen Antonia as Phone Operator (uncredited)

Saira Awan as Nurse Miscellaneous Crew (uncredited)

Krizia Bajos as Argentinian Girl (uncredited)

Tom Bonello as WQED Grip and Electric (uncredited)

Gregory Bromfield as Awards Banquet Waiter (uncredited)

Francesca Calo as Train Passenger (uncredited)

Kitty Crystal as Subway Punk (uncredited)

Amy Lyn Elliott as WQED Makeup Artist (uncredited)

Joe Fishel as Journalist (uncredited)

Nate Heller as Wedding Band Lead Guitarist (uncredited)

Bill Isler as Restaurant Patron (uncredited)

Kevin L. Johnson as Darin Scharf (uncredited)

Rosie Koster as Esquire Employee (uncredited)

Michael Masini as Richie (uncredited)

Kirsten McCain as Gala Attendee (uncredited)

Patrick McDade as Rick (uncredited)

David Newell as Restaurant Patron (uncredited)

Trevor Stevie Ray Ontiveros as New Yorker (uncredited)

Keith Otto as Gala Attendee (uncredited)

Khary Payton as Arthur Mendez - Telegraph Clerk (uncredited)

Alex Pérez as Parent (uncredited)

Katrina E. Perkins as Mr. Rogers Superfan (uncredited)

Jivan Xander Ramesh as Mr. Rogers' Fan (uncredited)

Scott Rapp as Bartender (uncredited)

Fred Rogers as Self (archive footage) (uncredited)

Joanne Rogers as Restaurant Patron (uncredited)

Edlyn Sabrina as Gala Guest (uncredited)

Erika Shrout as Mother (uncredited)

Laura Faye Smith as Julia Henderson - Fred's Secretary (uncredited)

Rebecca Watson as Diana (uncredited)

Stephen West-Rogers as Peter (uncredited)

Ted Williams as WQED Electrician (uncredited)

Jackson Nunn as Grip (uncredited)