Mickey Rourke as Johnny Handsome

Ellen Barkin as Sunny Boyd

Morgan Freeman as Lt. A.Z. Drones

Forest Whitaker as Dr. Steven Fisher

Elizabeth McGovern as Donna McCarty

Lance Henriksen as Rafe Garrett

Scott Wilson as Mikey Chalmette

David Schramm as Vic Dumask

Peter Jason as Mr. Bonet

Yvonne Bryceland as Sister Luke

Jeffrey Meek as Earl

J.W. Smith as Larry

Allan Graf as Bob Lemoyne

Edward Walsh as Judge

Eugenia Ives as Nurse

Blake Clark as Sheriff Monte

Ken Medlock as Shipyard Accountant

Ed Zang as Prestige Manager

John P. Fertitta as Prestige Salesman

Raynor Scheine as Gun Dealer