Lyric Ross as Kat Elliot (voice)

Keegan-Michael Key as Wendell (voice)

Jordan Peele as Wild (voice)

Sam Zelaya as Raúl Cocolotl (voice)

James Hong as Father Bests (voice)

Angela Bassett as Sister Helley (voice)

Gabrielle Dennis as Wilma Elliot (voice)

Gary Gatewood as Delroy Elliot (voice)

Igal Naor as Manberg (voice)

Tamara Smart as Siobhan (voice)

Seema Virdi as Sloane (voice)

Ramona Young as Sweetie (voice)

Maxine Peake as Irmgard Klaxon (voice)

David Harewood as Lane Klaxon (voice)

Ving Rhames as Buffalo Belzer (voice)

Michele Mariana as Sister Chinstrap / Sister Daley (voice)

Natalie Martinez as Mariana Cocolotl (voice)

Tantoo Cardinal as Ms. Hunter (voice)

Serelle Strickland as Young Kat (voice)

Phoebe Lamont as Bearz-A-Bub (voice)

Nick E. Tarabay as Fawzi (voice)

Joseph Tran as Dr. Ngo (voice)

Carolyn Crawford as Cassandra / Sukie Jordan (voice)

Mandy Hutchings as Governor Bribes (voice)

Samantha Fawaz as Female Cop (voice)