Amy Poehler as Abby

Maya Rudolph as Naomi

Rachel Dratch as Rebecca

Ana Gasteyer as Catherine

Paula Pell as Val

Emily Spivey as Jenny

Tina Fey as Tammy

Jason Schwartzman as Devon

Maya Erskine as Jade

Liz Cackowski as Lisa (Sommelier)

Rachel Hamilton as Bartender

Cherry Jones as Lady Sunshine

Brené Brown as Herself

Jon Glaser as TED Talk (voice)

Craig Cackowski as Mason (Sommelier)

Kate Comer as Clem

R.J. Walker as Pray

Janine Brito as Kira

Sunita Mani as Dolly

Jason Greene as Freckle

Santina Muha as Dr. Melton Receptionist (voice)

Greg Poehler as Doctor Dickswing

Caitlin Arend as Young Abby (uncredited)

Elise Robson as Young Catherine (uncredited)

Hannah Bamberg as Catherine's Assistant (uncredited)

Ryan Shukis as Waiter (uncredited)