Christy Carlson Romano as Kim Possible (voice)

Will Friedle as Ron Stoppable (voice)

Nancy Cartwright as Rufus (voice)

Tahj Mowry as Wade (voice)

Gary Cole as Dr. Possible (Dad) (voice)

John DiMaggio as Dr. Drakken (voice)

Michael Dorn as Rufus 3000 (voice)

Michael Clarke Duncan as Future Wade (voice)

Dakota Fanning as Preschool Kim Possible (voice)

Vivica A. Fox as Future Monique (voice)

Elliott Gould as Mr. Stoppable (voice)

Nicole Sullivan as Shego (voice)

Kirsten Storms as Bonnie Rockwaller (voice)

Jean Smart as Dr. Ann Possible (voice)

Raven-Symoné as Monique (voice)

Harrison Fahn as Preschool Ron (voice)

Tom Kane as Monkey Fist (voice)

Brian George as Duff Killigan (voice)

Shaun Fleming as Jim and Tim Possible (voice)

Freddie Prinze Jr. as Future Jim and Tim Possible (voice)

Kelly Ripa as Future Bonnie Rockwaller (voice)

Frank Welker as Animal Vocal Effects (uncredited) (voice)