Steven Weber as Charlie B. Barkin (voice)

Dom DeLuise as Itchy Itchiford (voice)

Bebe Neuwirth as Anabelle / Belladonna (voice)

Sheena Easton as Sasha La Fleur (voice)

Ernest Borgnine as Carface Carruthers (voice)

Charles Nelson Reilly as Killer (voice)

Beth Andersen as Martha (voice)

Taylor Emerson as Timmy (voice)

Myles Jeffrey as Scruffy (voice)

Aria Noelle Curzon as Female Puppy Angel (voice)

Ashley Tisdale as Female Puppy (voice)

Laurie A. Schillinger as Additional Voices (voice)