Melissa McCarthy as Carol Peters

James Corden as Superintelligence (voice) / James Corden

Bobby Cannavale as George Churchill

Brian Tyree Henry as Dennis Caruso

Sam Richardson as John Donahue

Ben Falcone as Charles Kuiper

Michael Beach as Saul Gomez

Rachel Ticotin as Director Tyson

Jean Smart as President Monahan

Sarah Baker as Emily

Jessica St. Clair as Leslie

Karan Soni as Ahmed

Ken Griffey Jr. as Ken Griffey, Jr.

Octavia Spencer as Octavia Spencer (voice)

William Daniels as KITT (voice)

Steve Mallory as Dean

Courtney Patterson as Carla

Usman Ally as Sergei

Jenna Perusich as Helga

Carolyn Trahan as Debbie

Jay Lay as Jay

Mac Alsfeld as Fletcher Dobbs

Damon Jones as Victor

Eduardo Franco as Todd

Patrick Bristow as Digital Superintelligence (voice)

Joanna Daniel as British Diplomat

Kristie Walden as Chinese Diplomat

Ash Thapliyal as Indian Diplomat

Mike Benitez as Restaurant Manager

Jessie Ennis as Pedestrian

Judith Franklin as Mom

Jakari Fraser as Son

Charles Green as Motorcycle Cop

Tina Witherby as Usher

Lu Parker as Anchorperson

Vishesh Chachra as Army Tech Officer

Kami Bankston as Army Sergeant

Roberto C. Velazquez as Mariachi Singer

Luis Vazquez as Mariachi Singer

Jose T. Lara-Castro as Mariachi Singer

Ruben Velazquez as Mariachi Singer

Octavio Garcia as Mariachi Singer

Humberto Perez Mendoza as Mariachi Singer

Medford Brown as Meat Man

Jwaundace Candece as Agent (uncredited)

Jeffrey Blanton as Army Enlisted (uncredited)

Jock McKissic as Rico (uncredited)

Joey Renfroe as Army Enlisted (uncredited)

Andrew Tinpo Lee as Mr. Peacock (uncredited)