Lucas Jade Zumann as James Whitman

Taylor Russell as Sophie

Jason Isaacs as Carl

Lisa Edelstein as Elly

David Arquette as Xavier

Lily Donoghue as Jorie Whitman

Odiseas Georgiadis as Kwame

Caroline Arapoglou as Sally

Michael H. Cole as Walt Whitman

Chase Stokes as Martin

Tom Wilkinson as Dr. Bird (Voice)

Sarah Michael Novia as Dr. Hightower

YaYa Gosselin as Young Jorie

Roger Dale Floyd as Young James

Chip Carriere as Customer

Thomas Belgrey as Vladimir Nagasaki

Bryan McClure as Keith

Tommy Kane as Painball Dad

Jordan Sherley as Girl #1

Amanda Young as Girl #2

Hunter Deno as Beautiful 16 Year Old Girl

Tyler Bunch as Dr. Bird (puppeteer)

J. Gaven Wilde as Sam

Rakesh Gosain as Beekeeper

Chris Ploetz as Elizabethan Poet

Megan Wilkens as Puke Girl