Joe Rogan as Self - Host

Ralph Abraham as Self - Mathematician

Joel Bakst as Self - Rabbi

Steven Barker as Self - Pharmacologist

Cynthia Geist as Self - DMT Study Nurse

Susan Blumenthal as Self - DMT Volunteer

Patricio Dominguez as Self - DMT Volunteer

Neal Goldsmith as Self - Psychologist

Alex Grey as Self - Artist

Roland Griffiths as Self - Behavioral Pharmocologist

Charles Grob as Self - Psychiatrist

Kathleen Harrison as Self - Ethnobotanist

Terence McKenna as Self - Writer & Cultural Commentator (archive footage)

Erik Davis as Self - Writer

Graham Hancock as Self - Writer

James Kent as Self - Writer

Dennis J. McKenna as Self - Ethnopharmacologist

Ralph Metzner as Self - Psychologist

Christian Meuli as Self - DMT Volunteer, Family Physician

Jeremy Narby as Self - Anthropologist

Andrew Newberg as Self - Radiologist

David Nichols as Self - Medicinal Chemist

Daniel Pinchbeck as Self - Writer

Douglas Rushkoff as Self - Writer

Spiros Antonopoulos as Self - DMT Volunteer, Yoga Student

Leanna Standish as Self - Naturopathic Physician

Andrew Stone as Self - DMT Volunteer, Software Developer

Rick Strassman as Self - Psychiatrist

Robert Weisz as Self - DMT Volunteer, Clinical Psychiatrist

Ricardo Amaringo as Self

Alvin Joseph as Self

Jon Levin as Self

Aja Loux as Self

José Pineda Vargas as Self

Jordan Phillips as Self

Jose Plaza as Self

Mitch Schultz as Self

Rob Velez as Self

Fermin Quintuna as Self

Ede Frecska as Self - Psychopharmacologist