Joe Rogan as Himself - Host

Ralph Abraham as Himself - Mathematician

Joel Bakst as Himself - Rabbi

Steven Barker as Himself - Pharmacologist

Cynthia Geist as Herself - DMT Study Nurse

Susan Blumenthal as Herself - DMT Volunteer

Patricio Dominguez as Himself - DMT Volunteer

Neal Goldsmith as Himself - Psychologist

Alex Grey as Himself - Artist

Roland Griffiths as Himself - Behavioral Pharmocologist

Charles Grob as Himself - Psychiatrist

Kathleen Harrison as Herself - Ethnobotanist

Terence McKenna as Himself - Writer & Cultural Commentator (archive footage)

Erik Davis as Himself - Writer

Graham Hancock as Himself - Writer

James Kent as Himself - Writer

Dennis J. McKenna as Himself - Ethnopharmacologist

Ralph Metzner as Himself - Psychologist

Christian Meuli as Himself - DMT Volunteer, Family Physician

Jeremy Narby as Himself - Anthropologist

Andrew Newberg as Himself - Radiologist

David Nichols as Himself - Medicinal Chemist

Daniel Pinchbeck as Himself - Writer

Douglas Rushkoff as Himself - Writer

Spiros Antonopoulos as Himself - DMT Volunteer, Yoga Student

Leanna Standish as Herself - Naturopathic Physician

Andrew Stone as Himself - DMT Volunteer, Software Developer

Rick Strassman as Himself - Psychiatrist

Robert Weisz as Himself - DMT Volunteer, Clinical Psychiatrist

Ricardo Amaringo as Himself

Alvin Joseph as Himself

Jon Levin as Himself

Aja Loux as Herself

José Pineda Vargas as Himself

Jordan Phillips as Herself

Jose Plaza as Himself

Mitch Schultz as Himself

Rob Velez as Himself

Fermin Quintuna as Himself

Ede Frecska as Himself - Psychopharmacologist