Jessica Chastain as Amy Loughren

Eddie Redmayne as Charles Cullen

Nnamdi Asomugha as Danny Baldwin

Kim Dickens as Linda Garran

Malik Yoba as Sam Johnson

Alix West Lefler as Alex Loughren

Noah Emmerich as Tim Braun

Gabe Fazio as Tom Anderson

Ajay Naidu as Dr. Robert Hind

Moe Irvin as Mark Rossi

Maria Dizzia as Lori Lucas

Shaun O'Hagan as Prosecutor Ellis

Marcia Jean Kurtz as Jackie

Myra Lucretia Taylor as Vivian Neal

Denise Pillott as Nurse 1

Dartel McRae as Nurse 2

Joseph Fugelo as Dr. Collins

Judith Delgado as Ana Martinez

Jesus-Papoleto Melendez as Sam Martinez

Devyn McDowell as Maya Loughren

Jennean Farmer as Receptionist

Navya La Shay as Hospital Admin

David Lavine as Duncan Beattie

Bruce MacVittie as Malcolm Burrel

Brooke Stacy Mills as Nurse Hardwick

Charlotte Cohn-Williams as Dr. Moore

Christine Healy as Assistant

Maria Farrow as Dr. Peters

Alex Bartner as Messenger

Anjelica Bosboom as Kelly Anderson

Rebecca Watson as Nurse Sandra

Jennifer Regan as ER Nurse

Beth Dixon as Diner Waitress

Brian Sayers as State Trooper

Steve Antonucci as Grave Digger (uncredited)

Evan Bass as Nurse Geddes (uncredited)

Andrew James Bleidner as Alex Lombardo (uncredited)

David Boston as Driver (uncredited)

Marko Caka as Detective (uncredited)

Chris Henry Coffey as Dr. Steven Reed (uncredited)

Victor Cruz as Gene Smith (uncredited)

Sheetal Deo as Doctor Day Player (uncredited)

Marcia M Francis as Patient (uncredited)

Gina Jun as Doctor (uncredited)

Becca Marks as Night Nurse (uncredited)

Lauren Yaffe as ICU Patient (uncredited)