Tessa Thompson as Irene Redfield

Ruth Negga as Clare Kendry

André Holland as Brian Redfield

Alexander Skarsgård as John Bellew

Bill Camp as Hugh Wentworth

Gbenga Akinnagbe as Dave

Antoinette Crowe-Legacy as Felise

Justus Davis Graham as Ted

Ethan Barrett as Junior

Ashley Ware Jenkins as Zulena

Amos J. Machanic as Ralph Hazelton

Stu S. Becker as Cabbie

Tom White as Attendant

Margaret Daly as Woman #1

Kerry Flanagan as Woman #2

Buzz Roddy as Officer

Derek Roberts as Guest

Amber Barbee Pickens as Dancer

Samuel Coleman as Dancer

Tatiana Marie Barber as Dancer

Carmen Carriker as Dancer

Leroy Church as Dancer

Brian Davis as Dancer

Zuri Foreman as Dancer

Abeni Jewel as Dancer

Malik Kitchen as Dancer

Ivan Phillip Owens as Dancer

Donna Hayes as Dancer (uncredited)

Shaun Hudson as Saxophone Player (uncredited)

Sienna Jeffries as Looper (uncredited)

Doris McCarthy as Pedestrian (uncredited)

Rahim Rosen as Garbage Man (uncredited)