Felicity Huffman as Sabrina "Bree" Osbourne / Stanley Schupak

Kevin Zegers as Toby Wilkins

Fionnula Flanagan as Elizabeth Schupak

Burt Young as Murray Schupak

Carrie Preston as Sydney Schupak

Elizabeth Peña as Margaret

Graham Greene as Calvin Many Goats

Venida Evans as Arletty

Jon Budinoff as Alex

Raynor Scheine as Bobby Jensen

Danny Burstein as Dr. Spikowsky

Maurice Orozco as Fernando

Stella Maeve as Taylor

Teala Dunn as Little Girl

Grant Monohon as Hitchhiker

Paul Borghese as New York City Cop

Andrea James as Voice Coach

Amy Povich as Phoenix Cop

Bianca Leigh as Mary Ellen

Craig Bockhorn as Sergeant

Kate Bayley as Tennessee Waitress

Jim Frangione as Taylor's Father

Calpernia Addams as Calpernia

David E. Harrison as David

Forrie J. Smith as Sammy

Barbara Barron as Mrs. Swallow

Steve Hurwitz as Harvey

Richard Poe as John

Vince Reign as Waiter