Yahya Abdul-Mateen II as Anthony McCoy

Teyonah Parris as Brianna Cartwright

Colman Domingo as William Burke

Nathan Stewart-Jarrett as Troy Cartwright

Kyle Kaminsky as Grady Smith

Vanessa Williams as Anne-Marie McCoy

Brian King as Clive Privler

Miriam Moss as Jerrika

Rebecca Spence as Finley Stephens

Carl Clemons-Hopkins as Jameson

Christiana Clark as Danielle Harrington

Michael Hargrove as Candyman / Sherman Fields

Rodney L Jones III as Billy

Ireon Roach as Trina

Breanna Lind as Annika

Heidi Grace Engerman as Haley Gulick

Sarah Lo as Samantha

Ro White as Boof

Mark Montgomery as Detective Lipez

Torrey Hanson as Jack Hyde

Cassie Kramer as Librarian

Sarah Wisterman as Celine

Cedric Mays as Gil Cartwright

Alec Silver as Restaurant server

Hannah Love Jones as Young Brianna

J. Nicole Brooks as Dr. Collins

Pamela Jones as Reporter Devlin Sharpe

Genesis Denise Hale as Sabrina

Katherine Purdie as Haley's Mom

Tien Tran as Jane Ji

Mike Geraghty as Police Officer Jones

Aaron Crippen as Police Officer Smith

Dan Fierro as Police Officer Rooney

Nadia Simms as Ringleader

Nancy Pender as TV News Anchor

Johnny Westmoreland as Samuel Evans

Guy Spencer as John Crawley

Daejon Staeker as The Kid

Tony Todd as Candyman / Daniel Robitaille

Virginia Madsen as Helen Lyle (voice)

Ben Marten as Officer Cooke (uncredited)