Ryan Reynolds as Wade Wilson / Deadpool / Juggernaut (voice)

Josh Brolin as Cable

Morena Baccarin as Vanessa

Julian Dennison as Firefist

Zazie Beetz as Domino

T.J. Miller as Weasel

Leslie Uggams as Blind Al

Karan Soni as Dopinder

Brianna Hildebrand as Negasonic Teenage Warhead

Jack Kesy as Black Tom

Eddie Marsan as Headmaster

Shioli Kutsuna as Yukio

Stefan Kapičić as Colossus (voice)

Randal Reeder as Buck

Nikolai Witschl as Head Orderly Frye

Thayr Harris as Sergei Valishnikov

Rob Delaney as Peter

Lewis Tan as Shatterstar

Bill Skarsgård as Zeitgeist

Terry Crews as Bedlam

Brad Pitt as Vanisher

Paul Wu as Hong Kong Boss

Robert Maillet as Sluggo

Alan Tudyk as Luke - Redneck #1

Matt Damon as Redneck #2

Michasha Armstrong as Swat Captain (School)

Joe Doserro as Bus Driver

Hayley Sales as Cable's Wife

Islie Hirvonen as Cable's Daughter

Jagua Arneja as Tree Trimmer #1

Gerry South as Tree Trimmer #2

Mike Dopud as Prison Guard

Luke Roessler as Cereal Kid

Andy Canete as Neighbor #1

Tanis Dolman as Neighbor #2

Eleanor Walker as Neighbor #3

Hunter Dillon as Branding Boy

Sala Baker as Older Firefist

Sonia Sunger as News Reporter (Irene)

Paul Wernick as News Cameraman

Rhett Reese as News Helicopter Pilot

Abiola Uthman as Chinook Pilot

Tony Bailey as Black Tom Gang Member

David Cook as Priest

Alex Kliner as Park Bench Couple

Elaine Kliner as Park Bench Couple

David Leitch as Ground Chuck Mutant

Valencia Budijanto as Zoo Kid

Stefania Indelicato as Bystander

Myfanwy Williams as Strip Club Dancer

Sam Armstrong as Strip Club Dancer

Alison Pickford as Strip Club Dancer

Paul Lazenby as Strip Club Baddie

Noah Beggs as Strip Club Baddie

Andrei Kovski as Strip Club Baddie

Alicia Morton as Vocalist on 'Tomorrow' (voice)

Fred Savage as Fred Savage (uncredited)

Andre Tricoteux as On-Set Colossus (uncredited)

James McAvoy as Charles Xavier / Professor X (uncredited)

Nicholas Hoult as Hank McCoy / Beast (uncredited)

Evan Peters as Peter Maximoff / Quicksilver (uncredited)

Tye Sheridan as Scott Summers / Cyclops (uncredited)

Alexandra Shipp as Ororo Monroe / Storm (uncredited)

Kodi Smit-McPhee as Kurt Wagner / Nightcrawler (uncredited)