Andy Samberg as Nyles

Cristin Milioti as Sarah

J.K. Simmons as Roy

Peter Gallagher as Howard

Meredith Hagner as Misty

Camila Mendes as Tala

Tyler Hoechlin as Abe

Chris Pang as Trevor

Jacqueline Obradors as Pia

June Squibb as Nana Schlieffen

Tongayi Chirisa as Jerry

Dale Dickey as Darla

Conner O'Malley as Randy

Jena Friedman as Daisy the Bartender

Brian Duffy as Spuds

Martin Kildare as Ted the Bartender

Lilli Birdsell as Jamie

Ryan Sturtz as Cop

Clifford V. Johnson as Professor

Calki Garcia as DJ Nice Height

Michelle Johnston as Nosy Neighbor

Isla Sellers as Roy's Daughter

Matt Smith as Out of Town Dad

Rebecca Smith as Out of Town Mom

Jake Smith as Out of Town Older Son

Noah Smith as Out of Town Younger Son

Rocky Bonifield as Wedding Guest (uncredited)

Erin Flannery as Wedding Guest (uncredited)

David Hutchison as Biker (uncredited)

Mark Kubr as Biker (uncredited)

David Philip Reed as Truck Driver (uncredited)