Christopher Thornton as 'Delicious' Dean O'Dwyer

Mark Ruffalo as Father Joe

Juliette Lewis as Ariel Lee

Orlando Bloom as The Stain

Laura Linney as Nina Hogue

Noah Emmerich as Rene Faubacher

James Karen as Father Rohn

John Carroll Lynch as Evangelist Carroll

Robert Wisdom as Prendell

Dov Tiefenbach as Oogie

Niko Nicotera as Rasha

Deantoni Parks as Chuck

Stephen Mendillo as Angry Drunk Harv

Sandra Seacat as Mrs. Matilda

Shaun Duke as Dr. Zaheedi

Allie Smith as Rene's Wife

Daniel Escobar as Hector

Jason Hiller as Church Organist

Tara Stewart as Lupus Woman

George W. Scott as Jerry

Nathan Wetherington as Bartender

Michael Anthony Spady as Mute Brute

Lydia Blanco Garza as Boy's Mother

Hiep Thi Le as Female Voluteer

Louis Mendoza as Maria Leceta

Mariko Denda as Young Chinese Girl

Willie Macc as Willie the Shill

Valeri Ross as Judge

Rick Peters as Prosecuting Attorney Peters

Cari Champion as Internet Journalist

Brian Goodman as C.O. Jacko

Bradley Wayne James as DJ Maestro Sonica

Owen Conway as Counter Guy

Sylvia St James as Homeless Woman

Laurel Astri as Laura

Karen Jin Beck as DJ Shy (uncredited)

Milissa Sears as Fan #3 (as Milissa Skoro)

Kelli Barksdale as Teddy Bear Girl (uncredited)

Diana Terranova as Brittany (uncredited)

Bonnie McNeil as Mrs. Zaheedi

Alex Aves as Nina’s Assistant

Anne Wile as Old Lady

Martin Charles Warner as Older Man

Tonita Castro as Desperate Mexican Woman

Marnie Alexenburg as Paramedic #1

Timothy McNeil as Ryan Webster

Oscar Best as Security Guard on Bullhorn

Kaleti Williams as Guard #1

Tracey Buckner as Roadie

Ray Auxias as Jamal - Guy Who Jumps on Stage (uncredited)

Anibal Silveyra as Churchgoer