Bill Pullman as Dr. Rex Martin

Bill Paxton as Jim Reston

Bud Cort as Jack Halsey

Nicholas Pryor as Man in Bloody White Suit / Ramsen / Ed Conklin

Patricia Charbonneau as Dana Martin

George Kennedy as Vance

Brian Brophy as Ellis

David Sinaiko as Berkovitch

Lee Arenberg as Sacks

Andy Wood as Brain Surgeon

Maud Winchester as Crazy Anna

Lisa Moncure as Board Member

Jon Kellam as Board Member

Willie Garson as Board Member

John Paxton as Board Member

David Sklare as Board Member

Cynthia Ettinger as Nurse Anderson

Shannon Holt as Toni

Vincent Foster as Fred

Brent Hinkley as Dewey

Kyle Gass as Anaesthetist

Deirdre O'Connell as Mrs. Halsey

Ann Vincent as Halsey's Aunt

Dorothy Vincent as Halsey's Aunt

Dean Robinson as Valet

Mark Boothby as Neighbor / Eunice Security Guard

Steve Ruggles as Restaurant Manager

Adam Lima as Bus Boy

Jesse Douglas as Canteen Attendant

Patti Tippo as Resident

Barney Burman as Experimental Face

Laura McCorkindale as Dancing Madwoman

Roscoe Pound as Wrong Man

William Simon as Doctor in Lobotomy Film

Alexander von Roon as Self