Tyler Posey as Inferno / Dante Pertuz (voice)

Navia Robinson as Zayla (voice)

Cierra Ramirez as America Chavez (voice)

Kathreen Khavari as Kamala Khan / Ms. Marvel (voice)

Milana Vayntrub as Squirrel Girl / Doreen Green (voice)

Dove Cameron as Gwen Stacy / Ghost-Spider (voice)

Dee Bradley Baker as Lockjaw / Tippy-Toe (voice)

Gary Cole as Invisibilio (voice)

Niecy Nash-Betts as Shocktress (voice)

Jeannie Tirado as Gabriela / Teacher (voice)

Meera Rohit Kumbhani as Ammi (voice)

Tony Mirrcandani as Abu (voice)