Cathy Cavadini as Blossom (voice)

Tara Strong as Bubbles (voice)

E. G. Daily as Buttercup (voice)

Roger L. Jackson as Mojo Jojo (voice)

Tom Kane as Professor Utonium (voice)

Tom Kenny as Mayor / Narrator / Ka-Ching Ka-Ching (voice)

Jennifer Hale as Ms. Keane (voice)

Jennifer Martin as Miss Bellum (voice)

Jeff Bennett as Ace / Big Billy / Grubber (voice)

Grey DeLisle as Linda / Woman at Zoo (voice)

Phil LaMarr as I.P. Host / Local Anchor (voice)

Rob Paulsen as Hota Wata / Killa Drilla (voice)

Kevin Michael Richardson as Rocko Socko / Ojo Tango (voice)

Frank Welker as Whole Lotta Monkeys (voice)