Tom Hanks as Larry Crowne

Julia Roberts as Mercedes Tainot

Bryan Cranston as Dean Tainot

Cedric the Entertainer as Lamar

Pam Grier as Frances

Taraji P. Henson as B'Ella

George Takei as Dr. Matsutani

Nia Vardalos as Map Genie (voice)

Sarah Mahoney as Samantha

Roxana Ortega as Alvarez

Rami Malek as Steve Dibiasi

Wilmer Valderrama as Dell Gordo

Gugu Mbatha-Raw as Talia

Grace Gummer as Natalie Calimeris

María Canals-Barrera as Lala Pinedo

Rita Wilson as Wilma Q. Gammelgaard

Randall Park as Trainee Wong

Holmes Osborne as David Busik

Rob Riggle as Jack Strang

Brady Rubin as Dorothy Genkos

Sy Richardson as Avery

Alex Quijano as Team Leader #1

Tina Huang as Team Leader #2

E-Kan Soong as Team Leader #3

Tarina Pouncy as Team Leader #4

Chet Hanks as Pizza Delivery Boy

Erin Underwood as Mom with baby

Carly Reeves as Sal

Dale Dye as Cox

Barry Sobel as Cubby

Bob Stephenson as Andrews

Ian Gomez as Frank

Jon Seda as Officer Diamond

Joshua Bitton as Officer Baker

Sarah Levy as Eli