Henry Thomas as Elliott

Drew Barrymore as Gertie

Robert MacNaughton as Michael

Peter Coyote as Keys

Dee Wallace as Mary

Erika Eleniak as Pretty Girl

K.C. Martel as Greg

C. Thomas Howell as Tyler

Sean Frye as Steve

David M. O'Dell as Schoolboy

Richard Swingler as Science Teacher

Frank Toth as Policeman

Robert Barton as Ultra Sound Man

Michael Darrell as Van Man

David Berkson as Medical Unit

David Carlberg as Medical Unit

Milt Kogan as Medical Unit

Alexander Lampone as Medical Unit

Rhoda Makoff as Medical Unit

Robert D. Murphy as Medical Unit

Richard Pesavento as Medical Unit

Tom Sherry as Medical Unit

Susan Cameron as Medical Unit

Will Fowler, Jr. as Medical Unit

Barbara Hartnett as Medical Unit

Diane Lampone as Medical Unit

Mary Stein as Medical Unit

Mitch Suskin as Medical Unit

Ted Grossman as Government Agent (uncredited)

James Kahn as Mustachioed Medical Unit Member Who Confirms E.T.'s Death (uncredited)

Anne Lockhart as Nurse (uncredited)

Melissa Mathison as Elliot's School Nurse (uncredited)

Debra Winger as Nurse Zombie Carrying Poodle (uncredited)

Michael Lepre as Pizza Man (uncredited)

Alex Daniels as Federal Agent in Car Chase (uncredited)

Chuck Riley as Narrator of Theatrical Trailer (uncredited)

Quinn Smith as Kid 3 (uncredited)